Patent attributes
The present invention relates to methods for changing the intercellular mobility of an mRNA of a gene in an organism, comprising: modifying a tRNA-like structure present in the mRNA by mutating the gene from which the mRNA is transcribed, or including the sequence of a tRNA-like structure in the transcribed part of the gene. Mutating the gene may be for inducing loss of mobility of the transcript and comprises deleting the sequence of the tRNA-like structure from the gene, mutating the sequence of the tRNA-like structure to change the tridimensional configuration thereof, or inserting a genetic element into the gene to remove the tRNA-like structure from the transcribed part of the gene, or for inducing a change in the destination of the transcript and comprises modifying the sequence of the tRNA-like structure from the gene such that the transcript is addressed to a location different from its original destination.
