Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Akin Akinc0
Muthusamy Jayaraman0
Pachamuthu Kandasamy0
Shigeo Matsuda0
Kallanthottathil G. Rajeev0
Martin Maier0
Muthiah Manoharan0
Date of Patent
August 6, 2019
0Patent Application Number
146778010
Date Filed
April 2, 2015
0Patent Citations Received
...
Patent Primary Examiner
Patent abstract
The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
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