Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ronny Mathieu Versteegen0
Wolter Ten Hoeve0
Hendricus Marie Janssen0
Marc Stefan Robillard0
Raffaella Rossin0
Date of Patent
August 13, 2019
Patent Application Number
14983858
Date Filed
December 30, 2015
Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi- and trispecific antibody derivatives.
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