Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Michal Amit0
Joseph Itskovitz-Eldor0
Date of Patent
August 20, 2019
Patent Application Number
15209776
Date Filed
July 14, 2016
Patent Citations Received
Patent Primary Examiner
Patent abstract
Well-defined, xeno-free culture media which comprise a TGF-beta isoform or the chimera formed between IL6 and the soluble IL6 receptor (IL6RIL6), which are capable of maintaining stem cells, and particularly, human embryonic stem cells, in an undifferentiated state are provided. Also provided are cell cultures comprising the culture media and the stem cells and methods of expanding and deriving embryonic stem cells in such well-defined, xeno-free culture media. In addition, the present invention provides methods of differentiating ESCs or EBs formed therefrom for the generation of lineage specific cells.
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