A first object of the present invention is to provide a tire puncture sealing agent having excellent sealing property and injectability. A tire puncture sealing agent of a first embodiment of the present invention contains a particular amine compound, glycols, a rubber latex and/or a resin emulsion, and a surfactant. A second object of the present invention is to provide a tire puncture sealing agent having excellent retainability of generated foam and excellent sealing property even in a small liquid amount. A tire puncture sealing agent of a second embodiment of the present invention contains a particular polyether-modified silicone, glycols, a rubber latex and/or a resin emulsion, and a surfactant.