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Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Kim O'Neill0
Date of Patent
September 17, 2019
Patent Application Number
15597822
Date Filed
May 17, 2017
Patent Citations Received
...
Patent Primary Examiner
Patent abstract
Described herein are chimeric receptors. Chimeric receptors comprise a cytoplasmic domain; a transmembrane domain; and an extracellular domain. In embodiments, the cytoplasmic domain comprises a cytoplasmic portion of a receptor that when activated polarizes a macrophage. In further embodiments, a wild-type protein comprising the cytoplasmic portion does not comprise the extracellular domain of the chimeric receptor. In embodiments, the binding of a ligand to the extracellular domain of the chimeric receptor activates the intracellular portion of the chimeric receptor. Activation of the intracellular portion of the chimeric receptor may polarize the macrophage into an M1 or M2 macrophage.
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