Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Rahul Palchaudhuri0
Anthony Boitano0
Megan D. Hoban0
Michael Cooke0
Adam Hartigan0
Date of Patent
October 8, 2019
0Patent Application Number
161984070
Date Filed
November 21, 2018
0Patent Citations
Patent Primary Examiner
Patent abstract
The invention provides methods of preventing and treating graft-versus-host-disease and autoimmune diseases, such as those arising from transplant therapy, by selective depletion of hematopoietic cells through the use of antibody-drug conjugates and ligand-drug conjugates that specifically bind CD137. The compositions and methods described herein can be used to treat a variety of pathologies, including stem cell disorders and other blood conditions.
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