US Patent 10436747 Nanopore sensing by local electrical potential measurement
Patent 10436747 was granted and assigned to President and Fellows of Harvard College on October, 2019 by the United States Patent and Trademark Office.
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There is provided a method for sensing the translocation of a molecule through a nanopore. In the method, there is directed to an inlet of a nanopore a molecule that is disposed in a first ionic solution of a first ionic concentration. The molecule is caused to translocate through the nanopore from the inlet of the nanopore to an outlet of the nanopore and into a second ionic solution of a second ionic concentration that is different than the first ionic concentration. An electrical potential, local to that ionic solution, of the first and second ionic solutions, which has a lower ionic concentration, is measured while the molecule is caused to translocate through the nanopore.
US Patent 10436747 Nanopore sensing by local electrical potential measurement
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