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US Patent 10449358 Devices and methods for modulation of bone erosion

Patent 10449358 was granted and assigned to SetPoint Medical Corporation on October, 2019 by the United States Patent and Trademark Office.

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Patent abstract

Devices and methods for stimulation of the vagus nerve to modulate (e.g., reduce, suppress, etc.) bone erosion. Methods and apparatus for modulating bone erosion may modulate levels of Receptor Activator for Nuclear Factor κB Ligand (RANKL), and/or to modulate (increase, enhance, etc.) osteoprotegerin (OPG) and/or OPG/RANKL ratio. Devices may include electrical stimulation devices that may be implanted, and may be activated to apply current for a proscribed duration, followed by a period without stimulation.

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