Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Dirk André Emmy Roymans0
Johannes Langedijk0
Date of Patent
October 29, 2019
0Patent Application Number
157422490
Date Filed
July 7, 2016
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Compositions including a recombinant respiratory syncitial virus (RSV) Fusion (F) polypeptide that is stabilized in the pre-fusion conformation are described. The RSV F polypeptide includes at least one mutation as compared to a wild type RSV F polypeptide and the at least one mutation is a) a mutation of the amino acid aspartic acid (D) on position 486, b) a mutation of the amino acid aspartic acid (D) on position 489, or c) a mutation of the amino acid serine (S) on position 398 and/or the amino acid lysine (K) on position 394. Compositions including an isolated nucleic acid molecule encoding the stable RSV F polypeptides are also described.
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