US Patent 10457717 Engineered polypeptides
Patent 10457717 was granted and assigned to Denali Therapeutics on October, 2019 by the United States Patent and Trademark Office.
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Patent abstract
Provided herein are polypeptides that bind to a blood-brain barrier (BBB) receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a BBB receptor-expressing cell, e.g., for transport across the BBB. Also provided herein are transferrin receptor (TfR) constructs that comprise a monomeric TfR apical domain or one or more portions of the TfR apical domain which have been circularly permuted relative to the full-length TfR sequence.
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Patent Number
104577170
Date of Patent
October 29, 2019
0Patent Application Number
159347440
Date Filed
March 23, 2018
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Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
104577170
Date of Patent
October 29, 2019
0Patent Application Number
159347440
Date Filed
March 23, 2018
0Patent Citations Received
Patent Primary Examiner
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US Patent 10457717 Engineered polypeptides
Infobox
Is a
Patent applicant
Current assignee
Patent jurisdiction
Patent number
10457717
Date of patent
October 29, 2019
Patent application number
15934744
Date Filed
March 23, 2018
Patent primary examiner
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