Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Atsuhiko Maeda0
Shinya Ishii0
Takashi Nakai0
Tomoyuki Igawa0
Date of Patent
November 12, 2019
Patent Application Number
15952945
Date Filed
April 13, 2018
Patent Citations
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Patent Primary Examiner
Patent abstract
The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.
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