A real-time silica monitoring system can include a plurality of off-site sensors positioned at geographic locations off-site from a hydraulic fracturing well site that detect and measure quantities of airborne silica particles, a plurality of on-site sensors positioned at geographic locations on a hydraulic fracturing well site that detect and measure quantities of air-borne silica particles, and one or more mobile sensors suitable to be carried by individual persons that detect and measure quantities of airborne silica particles. A monitoring system can include a computer system that can aggregate and store airborne silica measurements taken by one or more sensors and communicate data to a user.