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US Patent 10494667 Spatially encoded biological assays

Patent 10494667 was granted and assigned to PROGNOSYS BIOSCIENCES, INC. on December, 2019 by the United States Patent and Trademark Office.

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Patent attributes

Patent Applicant

PROGNOSYS BIOSCIENCES, INC.

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Current Assignee

PROGNOSYS BIOSCIENCES, INC.

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Mark S. Chee0

Date of Patent

December 3, 2019

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Patent Application Number

164376370

Date Filed

June 11, 2019

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Patent Citations

US Patent 10095832 Strategies for high throughput identification and detection of polymorphisms

US Patent 10023907 High throughput detection of molecular markers based on AFLP and high through-put sequencing

US Patent 10030261 Method and product for localized or spatial detection of nucleic acid in a tissue sample

Patent Citations Received

US Patent 12129516 Quantitative and automated permeabilization performance evaluation for spatial transcriptomics

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US Patent 11479809 Methods of detecting analytes

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US Patent 11492612 Methods of determining a surgical margin and methods of use thereof

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US Patent 11505828 Methods for spatial analysis using RNA-templated ligation

US Patent 11512308 Nucleic acid library methods

US Patent 11519033 Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample

US Patent 12076701 Capturing oligonucleotides in spatial transcriptomics

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US Patent 12110541 Methods for preparing high-resolution spatial arrays

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Patent Primary Examiner

James Martinell

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Patent abstract

The present invention provides assays and assay systems for use in spatially encoded biological assays. The invention provides an assay system comprising an assay capable of high levels of multiplexing where reagents are provided to a biological sample in defined spatial patterns; instrumentation capable of controlled delivery of reagents according to the spatial patterns; and a decoding scheme providing a readout that is digital in nature.

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