A clamp device for a flexible tube which can minimize the sealing area and prevent leakage of fluid and achieve easy release of the clamp device of a flexible tube. A clamp device for a flexible tube comprising: one branch formed with a first projection; the other branch formed with a second projection opposing to the first projection; an intermediate part connecting the one branch and the other branch each other; and an engaging part formed on a tip end of the other branch adapted to be engaged with an engaged part formed on a tip end of the one branch; flow of fluid within the flexible tube laid between the first projection and the second projection being able to be blocked by elastically bending the intermediate part and engaging the engaging part and the engaged part each other to clamp the flexible tube between the first and second projection wherein the clamp device comprises a positioning part for positioning the first and second projections in the longitudinal direction of the flexible tube under the clamped state of the flexible tube with engaging the engaging part and the engaged part each other.