Methods and systems for inspecting integrated circuits are provided. The method includes generating care areas that each includes at least one potential defect, organizing the generated care areas based on a first set of spatial relationships to provide a list of neighboring care areas, wherein each neighboring care area is an entry within the list, and generating a recipe file of the list, wherein each neighboring care area is inspected sequentially using a high-resolution inspection system. The system comprises a memory including instructions executable by a processor to: generate care areas that each includes at least one potential defect, organize the generated care areas based on a first set of spatial relationships to provide a list of neighboring care areas that are each an entry within the list, and generate a recipe file of the list, wherein each neighboring care area is inspected sequentially using a high-resolution inspection system.