A hand truck includes a main frame mechanism and a clamping mechanism. The main frame mechanism includes a main frame unit configured to carry an article, and a wheel unit connected to the main frame unit for moving the main frame unit. The clamping mechanism includes two clamping frame units disposed movably and respectively on left and right sides of the main frame unit. The clamping frame units are driven to move relative to the main frame unit between a clamped state and an unclamped state, in which the clamping frame units are moved close to and away from each other to clamp and release therebetween the article, respectively.