Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Kuo-Ching Chu0
Nan-Horng Lin0
Chi-Huey Wong0
Chien-Yu Chen0
Chiu-Chen Huang0
Han-Chung Wu0
Date of Patent
January 21, 2020
Patent Application Number
15683685
Date Filed
August 22, 2017
Patent Citations
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Patent Citations Received
Patent Primary Examiner
Patent abstract
The present disclosure relates to anti-SSEA4 antibodies and bindings fragments thereof comprising specific complementarity determining regions capable of high affinity binding to SSEA4 molecules and SSEA4-associated expressing tumor cells, such as breast cancer, pancreatic cancer, and renal cancer cells. The anti-SSEA4 antibodies and binding fragments induce ADCC or CDC effects in the targeted tumor cells and inhibit and/or reduce the cancer/tumor proliferation. The present disclosure also provides anti-SSEA4 antibodies and binding fragments thereof as a pharmaceutical composition for treating cancer. In addition, the anti-SSEA4 antibodies and binding fragments are useful in the diagnosis of cancers.
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