Is a
Patent attributes
Patent Applicant
0
Current Assignee
0
Patent Jurisdiction
Patent Number
Patent Inventor Names
Hai-Tsang Huang0
Hwan Geun Choi0
Jean Zhao0
Nathanael Gray0
Tinghu Zhang0
Yubao Wang0
Date of Patent
January 28, 2020
0Patent Application Number
155545950
Date Filed
March 4, 2016
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Provided herein are tricyclic small molecule inhibitors of maternal embryonic leucine zipper kinase (MELK). The compounds are useful for treating cancer and other conditions or diseases associated with aberrant MELK expression. Also provided herein are pharmaceutical compositions comprising a tricyclic compound of the invention and a pharmaceutically acceptable carrier. The invention also provides methods of treating cancers associated with over-expression of MELK.
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