The present disclosure includes systems and techniques relating to an integer non-uniform constellation (NUC) high-order M-QAM. In some implementations, M is no less than 1024. Each of M constellation points of the integer NUC M-QAM has respective integer real and imaginary coordinates. A bit pattern is received and mapped to integer real and imaginary coordinates of one of the M constellation points according to a mapping rule of the integer NUC M-QAM. A transmission signal is modulated in accordance with the integer real and imaginary coordinates of the one of the M constellation points of the integer NUC M-QAM.