Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
February 4, 2020
Patent Application Number
15945148
Date Filed
April 4, 2018
Patent Citations Received
...
Patent Primary Examiner
Patent abstract
The present invention provides preparations of MSCs with important therapeutic potential. The MSC cells are non-primary cells with an antigen profile comprising less than about 1.25% CD45+ cells (or less than about 0.75% CD45+), at least about 95% CD105+ cells, and at least 95% CD166+ cells. Optionally, MSCs of the present preparations are isogenic and can be expanded ex vivo and cryopreserved and thawed, yet maintain a stable and uniform phenotype. Methods are taught here of expanding these MSCs to produce a clinical scale therapeutic preparations and medical uses thereof.
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