Apparatus and methods for signal booster systems with compensation for cable loss are provided herein. In certain configurations, a signal booster system includes two or more antennas for wirelessly communicating RF signals and a signal booster including booster circuitry for providing amplification to at least a portion of the RF signals. At least one of the antennas is connected to the signal booster via a cable. Additionally, the signal booster includes a cable loss compensation circuit that adjusts a gain of the booster circuitry to compensate for a loss of the cable.