Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
March 10, 2020
Patent Application Number
16442168
Date Filed
June 14, 2019
Patent Citations Received
...
Patent Primary Examiner
Patent abstract
The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.
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