Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Ismail Mustafa Meraz0
Rita Elena Serda0
Date of Patent
January 5, 2021
0Patent Application Number
157542060
Date Filed
August 19, 2016
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Disclosed are positively-charged, cytotoxic nanoparticle compositions comprising immune modulators (such as the toll-like receptor (TLR)-4 ligand, monophosphoryl lipid (MPL)-A), and Interleukin (IL)-12)), which exhibit enhanced uptake by mammalian cancer cells, and cause increased cancer cell death and/or an increased release of cancer antigens following direct injection to populations of cancer or tumor cells. Also disclosed are nanoparticle-vectored, immunomodulatory compositions that stimulate antigen presenting immune cells and T cells, and support the development of anti-cancer immunity in mammalian hosts. The disclosed cationic liposomes represent an important advance in the area of cancer immunotherapeutics.
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