Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jun Feng0
Pingda Ren0
Yi Liu0
Yun Oliver Long0
Liansheng Li0
Date of Patent
January 5, 2021
Patent Application Number
15763812
Date Filed
September 27, 2016
Patent Citations
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Patent Citations Received
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Patent Primary Examiner
Patent abstract
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, tautomer, stereoisomer or prodrug thereof, wherein R1, R3a, R3b, R4a, R4b, G1, G2, G2, G3, G4, m1, m2, m3, m4, L1, L2 and E are as defined herein. Methods associated with preparation and use of such compounds, pharmaceutical compositions comprising such compounds and methods to modulate the activity of G12C mutant KRAS protein for treatment of disorders, such as cancer, are also provided.
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