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US Patent 10883996 Methods of identifying signaling modulators of the trimeric TNFa

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Is a

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Patent attributes

Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Timothy John Norman0

Alastair Lawson0

Boris Kroeplien0

Daniel Christopher Brookings0

David James McMillan0

Graham John Warrellow0

James Philip O'Connell0

John Robert Porter0

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Date of Patent

January 5, 2021

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Patent Application Number

157363360

Date Filed

October 22, 2015

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Patent Citations

US Patent 10775385 Treatment of autoimmune and inflammatory disorders with asymmetric TNF alpha trimers

US Patent 10705094 TNF receptor signaling modulator assay

US Patent 10428148 Anti-ALK2 antibody

Patent Citations Received

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US Patent 10969393 Complexes between anti-TNF antibodies, trimeric TNF proteins and organic molecules binding them

US Patent 11022614 Antibodies binding to trimeric TNF alpha epitopes

US Patent 11674967 Method of identifying potential inhibitors of APO TNFα trimers

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US Patent 11448655 Method for identifying a modulator of the TNFα or CD40L interaction with their cognate receptors

Patent Primary Examiner

Elly-Gerald Stoica

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Patent abstract

The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

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