A combination of a bone conduction Bluetooth earphone and a charging base includes an earphone body, a PCB, a wireless module, and a rechargeable battery. The PCB, the wireless module and the rechargeable battery are disposed in the earphone body. The wireless module and the rechargeable battery are electrically connected to the PCB. It realizes the design of the bone conduction Bluetooth earphone and solves the problem that an air conduction speaker needs good air tightness, a resonant chamber and tuning and is inconvenient for assembly. The structural design is clever and reasonable, and it is easy for production.