A secured device includes an electronic component and a protective cover surrounding the electronic component. The secured device also includes one or more chemiluminescent reactant layers and a light sensor that is electrically connected to the electronic component. The one or more chemiluminescent reactant layers are disposed between the protective cover and the electronic component and include multiple reactants that undergo a chemiluminescent reaction. The light sensor is configured to trigger one or more tamper response operations responsive to detection of a photon generated by the chemiluminescent reaction.