Various embodiments regarding a lightweight wall body frame used for a clean room are described. According to an embodiment, a lightweight wall body frame may comprise: a frame body; a coupling portion comprising a coupling opening formed at the center portion of the frame body; first and second attachment surfaces formed on the outer surface of the frame body so as to attach a steel plate of the lightweight wall body; and first and second support portions formed inside the frame body and inclined so as to connect between the coupling portion and the first and second attachment surfaces and to support the same. Besides, various other embodiments are possible.