In a general aspect, a vitrectomy system is adapted to use photodisruption to rupture eye tissue. In some aspects, a photodisruption-based vitrectomy system includes a laser source configured to generate optical pulses having a pulse energy greater than a threshold energy for causing photodisruption in vitreous humor. The system also includes an optical switching device arranged to receive an output of the laser source, and an optical fiber with multiple cores that is arranged to receive an output of the optical switching device. The optical switching device is configured to select a core of the optical fiber and direct optical pulses received from the laser source into the selected core.