Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Suzanne L. Topalian0
Kenneth W. Kinzler0
Luis Diaz0
Nickolas Papadopoulos0
Bert Vogelstein0
Drew M. Pardoll0
Dung Le0
Date of Patent
March 2, 2021
0Patent Application Number
161445490
Date Filed
September 27, 2018
0Patent Citations Received
...
Patent Primary Examiner
Patent abstract
Blockade of immune checkpoints such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) shows promise in patients with cancer. Inhibitory antibodies directed at these receptors have been shown to break immune tolerance and promote anti-tumor immunity. These agents work particularly well in patients with a certain category of tumor. Such tumors may be particularly susceptible to treatment because of the multitude of neoantigens which they produce.
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