Is a
Patent attributes
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Frank DeRosa0
Michael Heartlein0
Shrirang Karve0
Date of Patent
March 9, 2021
Patent Application Number
16773638
Date Filed
January 27, 2020
Patent Citations
Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides, among other things, compositions and methods of formulating nucleic acid-containing nanoparticles comprising no more than three distinct lipids components, one distinct lipid component being a sterol-based cationic lipid. In some embodiments, the present invention provides compositions and methods in which the lipid nanoparticles further comprise helper lipids and PEG-modified lipids. The resulting formulation comprises a high encapsulation percentage for nucleic acids.
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