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US Patent 10947270 Targeted prodrug cytosine deaminase fusion carrier and application thereof

Patent 10947270 was granted and assigned to National Yang-Ming University on March, 2021 by the United States Patent and Trademark Office.

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Patent Applicant
National Yang-Ming University
National Yang-Ming University
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Current Assignee
National Yang-Ming University
National Yang-Ming University
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
109472700
Patent Inventor Names
Shun-Fu Chang0
Hsin-Ell Wang0
Jia-Je Li0
Roy Chen-Chih Wu0
C. Allen Chang0
Date of Patent
March 16, 2021
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Patent Application Number
162474890
Date Filed
January 14, 2019
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Patent Primary Examiner
‌
Elly-Gerald Stoica
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Patent abstract

The present invention provides a targeted prodrug enzyme fusion carrier comprising a targeted molecule and a prodrug enzyme. The targeted prodrug enzyme fusion carrier can effectively identify and bind to tumor cells and tumor-induced tumor angiogenesis. The targeted prodrug enzyme fusion carrier also has a targeted prodrug enzyme fusion protein and a theranostic system utilizing the method of in vivo nuclear medicine for the clinical diagnosis and treatment of individual patients with tumors.

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