Fluid handling couplings can be made to connect and disconnect other members of a fluid handling system. For example, this document describes fluid couplings that are convenient to couple/decouple and that provide strong resistance to inadvertent disconnection when subjected to rotation while pressurized. In some embodiments, the resistance to inadvertent disconnection is facilitated by a latch mechanism of the female coupling that includes a protrusion that becomes seated in a groove of a mated male coupling.