Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jau-Nan Lee0
Tony Tung-Ying Lee0
Yuta Lee0
Date of Patent
April 20, 2021
0Patent Application Number
169225950
Date Filed
July 7, 2020
0Patent Citations Received
Patent Primary Examiner
Patent abstract
Disclosed herein are human trophoblast stem (hTS) cells, differentiated cells thereof, derivatives thereof such as cellular mass, and uses thereof. The isolation of hTS cells can express FGF4, FGFR-2, Oct4, Thy-1, and stage-specific embryonic antigens distributed in different compartments of the cell. The hTS cells are able to derive into specific cell phenotypes of the three primitive embryonic layers, produce chimeric reactions in mice, and retain a normal karyotype and telomere length. In the hTS cells, Oct4 and fgfr-2 expressions can be knockdown by bFGF. The hTS cells could apply to human cell differentiation and for gene and cell-based therapies.
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