Is a
Patent attributes
Patent Applicant
0
Current Assignee
0
Patent Jurisdiction
Patent Number
Patent Inventor Names
Vincent K. C. Fung0
Kevin Hamblett0
Rupert H. Davies0
Stuart D. Barnscher0
Gerald J. Rowse0
James R. Rich0
Date of Patent
May 11, 2021
0Patent Application Number
165947280
Date Filed
October 7, 2019
0Patent Citations
Patent Primary Examiner
Patent abstract
Anti-HER2 biparatopic antibody-drug conjugates (ADCs) in which the drug is an auristatin analogue and is conjugated to the antibody at a low average drug-to-antibody ratio (DAR), and methods of using the ADCs in the treatment of a HER2-expressing cancer. The low average DAR (<3.9) ADCs as described herein have improved tolerability and decreased toxicity as compared to a corresponding ADC having a DAR≥3.9 when administered at the same toxin dose.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.
