Embodiments of safety trucks incorporate multiple connection points to which a variety of attachments, or combinations of attachments, can be releasably and interchangeably coupled to enable their use with increased effectiveness to safeguard roadway construction, maintenance and repair personnel as they perform tasks within or relatively near to roadway workzones and worksites. Also, methods of operation of the safety truck embodiments enhance their ability to guard and protect roadway construction, maintenance and repair personnel while they work within or relatively near to roadway workzone and worksite locations.