Patent 11021463 was granted and assigned to Attune Pharmaceuticals, Inc on June, 2021 by the United States Patent and Trademark Office.
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.