Is a
Patent attributes
Patent Applicant
Patent Jurisdiction
Patent Number
Date of Patent
June 8, 2021
Patent Application Number
16530030
Date Filed
August 2, 2019
Patent Citations
Patent Primary Examiner
Patent abstract
A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that present a choice of two human light chain variable gene segments such that the immunoglobulin light chains expresses by the mouse comprise one of the two human light chain variable gene segments. Methods for making bispecific antibodies having universal light chains using mice as described herein, including human light chain variable regions, are provided. Methods for making human variable regions suitable for use in multispecific binding proteins, e.g., bispecific antibodies, and host cells are provided.
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