Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Hua Zhou0
Lijun Wu0
Martyn Lewis0
Vita Golubovskaya0
Date of Patent
June 15, 2021
0Patent Application Number
161488060
Date Filed
October 1, 2018
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention provides chimeric antigen receptor (CAR)-T cells modified to express a CAR fusion protein comprising from N-terminus to C-terminus: (i) a single-chain variable fragment (scFv) comprising VH and VL, wherein scFv has an activity against a tumor antigen CD19, (ii) a transmembrane domain, (iii) at least one co-stimulatory domains, and (iv) an activating domain; wherein the fusion protein further comprises a FLAG tag N-terminus to scFv, C-terminus to scFv, or between VH and VL. Using CD19-FLAG CAR-T cells instead of CD19 CAR-T cells, cytokine levels (Interferon-γ, IL-2 and IL6) caused by infused CAR-T cells are reduced.
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