Patent 11040057 was granted and assigned to OliX Pharmaceuticals on June, 2021 by the United States Patent and Trademark Office.
In various aspects and embodiments, the invention provides compounds or agents that potentiate siRNA cellular entry or activity, and provides methods for identifying such compounds or agents. Exemplary agents that act as L-type calcium channel blockers are described herein, and are shown to potentiate gene silencing with cp-asiRNAs.