A workflow management system (WMS) coordinates, controls, and monitors item picking assets, item retrieval assets, and order packaging assets in performance of different workflows. The WMS optimizes the different workflows by assigning tasks to the different assets in a manner that minimizes overall execution time, cost, and resource utilization. Some optimizations include maximizing or prioritizing item pick rate, item packaging rate, or both. Assets integrated with the WMS and under WMS control include human workers, autonomous robots, and resources used in performance of the workflows.