Patent 11058705 was granted and assigned to Astex Pharmaceuticals on July, 2021 by the United States Patent and Trademark Office.
The invention provides derivatives of decitabine with superior chemical stability and shelf life, with similar physiological activity. The derivatives are provided in a non-aqueous formulation, which further stabilizes the derivatives. Methods of treating one or more myelodysplastic syndromes, leukemia, or solid tumours using the formulations are described.