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US Patent 11065308 Methods and compositions for CNS delivery of heparan n-sulfatase

Patent 11065308 was granted and assigned to Shire (pharmaceutical company) on July, 2021 by the United States Patent and Trademark Office.

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Patent

Patent attributes

Patent Applicant
Shire (pharmaceutical company)
Shire (pharmaceutical company)
Current Assignee
Shire (pharmaceutical company)
Shire (pharmaceutical company)
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
11065308
Date of Patent
July 20, 2021
Patent Application Number
16036584
Date Filed
July 16, 2018
Patent Citations Received
‌
US Patent 11884944 Fusion proteins comprising sulfoglucosamine sulfohydrolase enzymes and methods thereof
0
‌
US Patent 11471516 CNS delivery of therapeutic agents
Patent Primary Examiner
‌
Leon Blaine Lankford, Jr.
Patent abstract

The present invention provides, among other things, compositions and methods for CNS delivery of lysosomal enzymes for effective treatment of lysosomal storage diseases. In some embodiments, the present invention includes a stable formulation for direct CNS intrathecal administration comprising a heparan N-sulfatase (HNS) protein, salt, and a polysorbate surfactant for the treatment of Sanfilippo Syndrome Type A.

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