Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Søren V. Rasmussen0
Heidi Rye Hudlebusch0
Lykke Pedersen0
Peter Hagedorn0
Date of Patent
July 20, 2021
0Patent Application Number
164303390
Date Filed
June 3, 2019
0Patent Citations
Patent Primary Examiner
Patent abstract
The present invention relates to antisense oligonucleotides that are capable of modulating expression of ATXN2 in a target cell. The oligonucleotides hybridize to ATXN2 mRNA. The present invention further relates to conjugates of the oligonucleotide and pharmaceutical compositions and methods for treatment of neurodegenerative diseases such as spinocerebellar ataxia type 2 (SCA2), amyotrophic lateral sclerosis (ALS), Alzheimer's frontotemporal dementia (FTD), parkinsonism and conditions with TDP-43 proteinopathies using the oligonucleotide.
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