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US Patent 11083800 AAV virions with decreased immunoreactivity and uses therefor

Patent 11083800 was granted and assigned to Genzyme on August, 2021 by the United States Patent and Trademark Office.

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Patent abstract

Methods of making and using recombinant AAV virions with decreased immunoreactivity are described. The recombinant AAV virions include mutated capsid proteins or are derived from non-primate mammalian AAV serotypes and isolates that display decreased immunoreactivity relative to AAV-2.

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