US Patent 11103597 Nucleic acid molecules containing spacers outside ITR
Patent 11103597 was granted and assigned to ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. on August, 2021 by the United States Patent and Trademark Office.
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The present invention relates to nucleic acid molecules containing spacers that can be packaged into viral particles and methods of producing them. In a first aspect, the invention features a nucleic acid molecule including a first spacer (SSI); a first inverted terminal repeat (ITR1); a cloning site (CS); a second inverted terminal repeat (ITR2); and a second spacer (SS2), such as a eukaryotic spacer; operably linked to each other in a 5′-to-3′ direction as: SS1-ITR1-CS-ITR2-SS2. In an embodiment, the invention features a vector comprising any of the above-described nucleic acid molecules. In another aspect, the invention features a plurality of viral particles including the nucleic acid molecule. The invention further includes a host cell including any of the above-described vectors.
US Patent 11103597 Nucleic acid molecules containing spacers outside ITR
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