US Patent 11104904 Method for stabilizing DNA aptamers

Patent 11104904 was granted and assigned to TAGCyx Biotechnologies on August, 2021 by the United States Patent and Trademark Office.

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Patent

Patent attributes

Patent Applicant

TAGCyx Biotechnologies

Current Assignee

TAGCyx Biotechnologies

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

111049040

Patent Inventor Names

Michiko Hirao0

Ichiro Hirao0

Kenichiro Matsunaga0

Date of Patent

August 31, 2021

Patent Application Number

201907240

Date Filed

July 24, 2019

Patent abstract

An object of the present invention is to provide a convenient and low-cost method for enhancing the stability of a DNA aptamer and/or its capacity to bind to a target molecule, and a DNA aptamer obtained by the method. The object is solved by substituting an internal hairpin structure (stem-loop structure) of the DNA aptamer with a structure called mini-hairpin structure and optionally increasing GC pairs in a stem portion of the DNA aptamer.

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