US Patent 11154575 Cancer immunotherapy using CD19-directed chimeric antigen receptors
Patent 11154575 was granted and assigned to Nkarta, Inc. on October, 2021 by the United States Patent and Trademark Office.
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Patent abstract
Several embodiments provided for relate to methods of using of anti-CD19 CAR expressing immune cells in immunotherapy. Provided for herein in several embodiments are immune cell-based (e.g., natural killer (NK) cell) compositions comprising CD19-directed chimeric antigen receptors. In some, embodiments the anti-CD19 binder portion of the CAR is humanized. In several embodiments, the humanized anti-CD19 CAR expressing cells exhibit enhanced expression of the CAR as well as enhanced cytotoxicity and/or persistence.
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Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
111545750
Date of Patent
October 26, 2021
0Patent Application Number
202011040
Date Filed
November 4, 2020
0Official Website
Edits on 23 Sep, 2022
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Infobox
Is a
Patent Applicant
Current Assignee
Patent Jurisdiction
Patent Number
111545750
Date of Patent
October 26, 2021
0Patent Application Number
202011040
Date Filed
November 4, 2020
0Official Website
Edits on 6 Jun, 2022
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Edits on 27 Oct, 2021
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US Patent 11154575 Cancer immunotherapy using CD19-directed chimeric antigen receptors
Infobox
Is a
Patent applicant
Current assignee
Patent jurisdiction
Patent number
11154575
Date of patent
October 26, 2021
Patent application number
20201104
Date Filed
November 4, 2020
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