US Patent 11154603 Burkholderia pseudomallei composition

A cDNA composition for reducing the virulence of Bp and reduce the cell kill and scope of the infectious disease Burkholderia pseudomallei. (Bp), which encodes fusion proteins comprised of fragments of the extracellular domains of two Bp proteins are attached to the extracellular domain (ecd) of the potent immunostimulatory protein CD40 ligand (CD40L) in order to increase the levels of neutralizing antibodies which will interfere with the function of the extracellular domains of three Bp protein peptide fragments, OMP85, VgrG5 and Hcp-1, in order to protect against a lethal challenge of Bp.